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Tipologia
- 6 Brevetti2
Data di pubblicazione
- 20161
- 20151
Keyword
- Glocal and overlap alignment2
- Map-to-sequence alignment2
- Optical mapping2
Lingua
- eng2
Accesso al fulltext
- no fulltext2
We describe a computer-implemented method of determining at least one optimal alignment of at least part of a first map to at least part of a second map or a plurality of second maps, the method comprising: receiving first map data indicative of a first ordered list of distances between features of the first map; receiving second map data indicative of a second ordered list of distances between features of the second map or second maps; generating, from the second map data, seed data indicati...
Resolution of complex repeat structures and rearrangements in the assembly and analysis of large eukaryotic genomes is often aided by a combination of high-throughput sequencing and mapping technologies (e.g. optical restriction mapping). In particular, mapping technologies can generate sparse maps of large DNA fragments (150 kbp-2 Mbp) and thus provide a unique source of information for disambiguating complex rearrangements in cancer genomes. Despite their utility, combining high-through...